A plethora of systems, platforms, and devices are daily producing and exchanging vast amounts of data towards better decision making and systems engineering. Their overall communication must follow a pre-specified set of rules, defined by different protocols, being surrounded by specific standards for more efficient transmission and interoperable communication. In the same direction, the healthcare domain defines several protocols and standardized approaches supporting the Health Information Exchange (HIE) paradigm, in which several challenges occur related with secure data management, explanation, interpretation, interoperability, and communication. The solution to these challenges is efficient, and well-designed HIE systems and protocols which can instantly improve the overall coordination and management of health-related data, information, and extracted knowledge. Current protocols supporting …