XR5.0 will build, demonstrate, and validate a novel Person-Centric and AI-based XR paradigm that will be tailored to the requirements and nature of I5.0 applications. The XR5.0 project aims to develop user-friendly Extended Reality (XR) applications for industrial workers using Virtual Reality (VR), Augmented Reality (AR), and Mixed Reality (MR). Despite improving production and safety, current XR applications often lack personalization for Industry 5.0 (I5.0). To overcome this, the project proposes person-centric XR visualizations considering individual worker traits, skills, and context, addressing challenges in technology, content, flow control, and compliance with European values. XR5.0 focuses on a pioneering XR approach tailored for I5.0, integrating it with innovative “XR-made-in-Europe” technology. This includes human-centered digital twins and advanced AI paradigms. The XR5.0 technologies will be coupled with a cloud-based XR training platform for Operator 5.0 applications, which will enable ergonomic and personalized training of industrial workers on popular processes.